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Microsoft 365 Certified: Endpoint Administrator Associate · Microsoft
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Written by other learners. Comments can disagree with the marked answer — check the official documentation when in doubt.
To automatically onboard devices to Microsoft Defender for Endpoint (MDE) as they enroll in Intune, the supported, recommended method is to use an Endpoint security → Endpoint detection and response (EDR) policy (or the preconfigured EDR policy) after connecting MDE to Intune. EDR policies handle onboarding automatically (including the Auto from connector package) and are designed for this scenario
No, Device configuration profile is not enough. need to configure End-point Detection and Response
Answer is No. https://learn.microsoft.com/en-us/defender-endpoint/configure-endpoints-mdm "...you can use a custom configuration policy or an EDR policy."