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Implementing and Operating Cisco Security Core Technologies (SCOR) · Cisco
Select one answer.
Written by other learners. Comments can disagree with the marked answer — check the official documentation when in doubt.
B. Install and configure the Cisco DUO Authentication Proxy and configure the identity source sequence within Cisco ISE.
https://community.cisco.com/t5/security-documents/duo-mfa-integration-with-ise-for-tacacs- device-administration/ta-p/3881767
B is the correct answer. You would have to authenticate first successfully before DUO is triggered for MFA, DUO would not handle authentication directly.